Key Laboratory of Molecular Imaging of Heilongjiang Province Cancer Molecular Diagnosis and Target Therapy Test Base of Heilongjiang Province Molecular Medicine Engineering Technology Research Center of Heilongjiang Province TOF-PET/CT/MR Center

Members

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Faculty Members

Xilin Sun, M.D.

Birthday: Mar. 29th, 1981
Radiologist, Associate Professor
TOF-PET/CT/MR Center
Department of Radiology
The Fourth Hospital of Harbin Medical University
Molecular Imaging Research Center of Harbin Medical University
766 Xiangan north street, Songbei district, Harbin, Heilongjiang, P.R. China, 150028
Office: +86-451-88118600
Cell Phone: +86-15904601908
E-mail: sunxilin@aliyun.com


RESEARCH INTERESTS
    Molecular Imaging of Cancer
    Functional MR Imaging of Cancer
    Molecular therapy of malignant diseases

EDUCATION


Colleges and Universities Attended:
2005- 2010: M.D. Medical imaging and nuclear medicine
Harbin Medical University, Harbin, Heilongjiang Province, China
Supervisor: Professor Baozhong Shen
2000-2005: B.S. Medical Imaging, Harbin Medical University, Harbin,
Heilongjiang Province, China

Predoctoral Training:
2009.8-2010.8: Supplemental Predoctoral Visiting Fellow
Laboratory for Molecular Imaging and Nanomedicine (LOMIN)
National Institutes of Biomedical Imaging and Bioengineering (NIBIB)
National Institutes of Health (NIH)
Mentor: Professor Xiaoyuan (Shawn) Chen
2009.2-2009.8: Visiting scholar, Molecular Imaging Group, Radiology
Molecular Imaging program at Stanford and Bio-X
Stanford University school of Medicine
Mentor: Professor Xiaoyuan (Shawn) Chen

EXPERIENCE

Employment
2014.10-present: Radiologist, Associate professor
TOF-PET/CT/MR Center
Department of Radiology
The Fourth Hospital of Harbin Medical University
Molecular Imaging Research Centerof Harbin Medical University
2011.12-2014.09:Radiologist, Associate professor
Department of Radiology,The Fourth Hospital of Harbin Medical University
Molecular Imaging Research Centerof Harbin Medical University
2010.6--2011.11:Radiologist, Attending physician
Department of Radiology,The Fourth Hospital of Harbin Medical University
Molecular Imaging Research Centerof Harbin Medical University

Research

The Fourth hospital of Harbin Medical University, Harbin, China, Radiologist 08/2010-present
Multimodal molecular imaging (PET/CT, PET/MR,MR, CT and optical) of cancer initiation, progress,   development and therapeutic response.
Molecular therapy of malignant diseases·

Functional MRimaging (DCE-MRI, MRS, SWI and DTI) of central nervous system tumors, stroke and intracranial vascular malformations initiation, progress, development and therapeutic response.
Diagnoses diseases of human body, using X-rays, CT, MR, PET/CT and PET/MR.
Examines internal structures and functions of organ systems, making diagnoses after correlation of imaging findings with other examinations and tests.
Administers radiopaque substances by injection, orally, or as enemas to render internal structures and organs visible on x-ray films or fluoroscopic screens.
Evaluates quality and accuracy of imaging

NIBIB, NIH, Supplemental Predoctoral Visiting Fellow 08/2009-08/2010
Molecular therapy of malignant diseases

MIPS, the Stanford University, Stanford, visiting scholar 02/2009–08/2009
Multimodal molecular imaging (PET, CT and optical) of cancer initiation, progress, development      and therapeutic response with peptides.
Proficient molecular imaging techniques in PET, CT, fluorescence microscope, gamma camera, imaging processing and analysis.
Proficiency in design and implementing experiments using animal models including tumor innoculation (orthotopic), tumor monitoring with caliper measurement, tail vein injection, animal anesthesia with isofluoane gas, animal body weight monitoring and euthanasia or tissue harvesting.
Comprehensive skills in cellular and molecular biology experimental techniques: cell and tissue culture, stable transfection andphage display.

MIPS, the Stanford University, Stanford, visiting scholar 12/2015–
Multimodal molecular imaging (PET, CT and optical) of cancer initiation, progress, development      and therapeutic response with peptides.
Proficient molecular imaging techniques in PET, CT, fluorescence microscope, gamma camera, imaging processing and analysis.

The 4th hospital of Harbin Medical University, Harbin, China, Radiologist 09/2005 to 02/2009
Diagnoses diseases of human body, using X-rays, CTand MRI.
Examines internal structures and functions of organ systems, making diagnoses after correlation of imaging findings with other examinations and tests.
Administers radiopaque substances by injection, orally, or as enemas to render internal structures and organs visible on x-ray films or fluoroscopic screens.
Evaluates quality and accuracy of imaging
Functional MRI (DCE-MRI, MRS, SWI and DTI) imaging of central nervous system tumors, stroke and intracranial vascular malformations initiation, progress, development and therapeutic response.

BOARD MEMBERSHIPS
2015-Youth Member, Chinese society of radiology
2015-Member, PET Imaging Group, Chinese society of nuclear medicine
2012-Youth Member, Molecular Imaging Group, Chinese society of radiology
2012-Member, MR Imaging Group, Heilongjiangsociety of radiology
2011-Youth Member, Molecular Imaging Group, Chinese society of biophysics
2010-Member, Society of Molecular Imaging


SCHOLARSHIPS AND HONORS
Excellent Young Scientist of Harbin Medical University
Excellent medical worker of Harbin Medical University
Excellent Young Scientist ofHeilongjiang Province
National Excellent Doctoral Dissertation Award nomination
RSNA (Radiological Society of North America) travel award
Harbin Medical University Excellent Doctoral Dissertation Award
Scholarship of Harbin Medical University
Scholarship of Harbin Medical University for Excellent Student-Cadres
Scholarship of Harbin Medical University
Scholarship of Harbin Medical University
Scholarship of Harbin Medical University for Excellent Student-Cadres
Scholarship of Harbin Medical University
Scholarship of Harbin Medical University for Excellent Social Work
Unicom New Space Scholarship of Harbin Medical University for Excellent Student

SCHOLARLY PUBLICATIONS

SCI:
1. Sun X, Niu G, Yan Y, Yang M, Chen K, Ma Y, Chan N, Shen B, Chen X. Phage Display Derived Peptides for Osteosarcoma Imaging. Clin Cancer Res.2010 Aug 15,16(16): 4268-77.IF=8.738
2. Sun X, Yan Y, Liu S, Cao Q, Yang M, Neamati N, Shen B, Niu G, Chen X. 18F-FPPRGD2 and 18F-FDG PET imaging of Abraxane therapy response. J Nucl Med. 2011 Jan,52(1):140-6. IF=7.022
3. Sun X, Niu G, Chan N, Shen B, Chen X. Tumor Hypoxia Imaging. Mol Imaging Biol. 2011 Jun;13(3):399-410.IF=3.844
4. Sun X, Li S,Shen B*. Identification of Disease States and Response to Therapy in Humans by Utilizing the Biomarker EGFR for Targeted Molecular Imaging. Current protein & peptide science.Curr Protein Pept Sci. 2016;17(6):534-42IF: 3.154
5. Sun X, Sun Y, Yang L, Yan X, Wang K, Shen B*. DCE-MRI-Derived Parameters in Evaluating Abraxane-Induced Early Vascular Response and the Effectiveness of Its Synergistic Interaction with Cisplatin. Plos One, 2016 Sep 15; 11(9)IF: 3.234
6. Yan Y, Sun X*,Shen B*. A Novel SPECT Probe for Targeting Mutated EGFR . Bioorg Med Chem Lett. 2015 Apr 1;25(7):1647-52 IF: 2.661
7. Chen H, Wang GD, Sun X, Todd T, Zhang F, Xie J, Shen B. Mesoporous Silica as Nanoreactors to Prepare Gd-encapsulated Carbon Dots of Controllable Sizes and Magnetic Properties. Adv Func Mater. In Press.IF: 11.8
8. Li L, Wang K, Sun X, Wang K, Sun Y, Zhang G, Shen B.Parameters of dynamic contrast-enhanced MRI as imaging markers for angiogenesis and proliferation in human breast cancer.Med Sci Monit. 2015 Feb 1;21:376-82.IF=1.699
9. Jin G, Cao Z, Sun X, Wang K, Huang T, Shen B.Protein O-glucosyltransferase 1 overexpression downregulates p16 in BT474 human breast cancer cells.Oncol Lett. 2014 Aug;8(2):594-600. Epub 2014 May 28.IF=0.987
10. Niu G, Sun X, Cao Q, Courter D, Koong A, Le QT, Gambhir SS, Chen X. Cetuximab-based immunotherapy and radioimmunotherapy of head and neck squamous cell carcinoma. Clin Cancer Res. 2010 Apr 1,16(7):2095-105. IF=8.722
11. Chen K, Sun X, Niu G, Ma Y, Yap LP, Hui X, Wu K, Fan D, Conti PS, Chen X. Evaluation of (64)Cu Labeled GX1: A Phage Display Peptide Probe for PET Imaging of Tumor Vasculature. Mol Imaging Biol. 2012 Feb;14(1):96-105. IF=3.844
12. Shen B, Wang K, Sun X, Wu L. Development of molecular imaging and nanomedicine in China.WileyInterdiscip Rev NanomedNanobiotechnol. 2011 Aug 17. IF=5.681
13. Yang M, Gao H, Sun X, Yan Y, Quan Q, Zhang W, A Mohamedali K, Rosenblum MG, Niu G, Chen X. Multiplexed PET Probes for Imaging Breast Cancer Early Response to VEGF(121)/rGel Treatment. Mol Pharm. 2011 Apr 4;8(2):621-8.IF= 5.408
14. Ma Z, Ma Y, Sun X, Ye Y, Shen B, Chen X, Ito Y. Purification of optical imaging ligand-Cybesin by high-speed counter-current chromatography.JChromatogr B.2010 Nov 1,878(29):3039-43.IF=2.971
15. Luo Z, Wang D, Sun X, Zhang T, Liu F, Dong D, Chan NK, Shen B. Comparison of the accuracy of subtraction CT angiography performed on 320-detector row volume CT with conventional CT angiography for diagnosis of intracranial aneurysms.Eur J Radiol. 2012 Jan;81(1):118-22. IF=2.941
16. Yan Y, Chen K, Yang M, Sun X, Liu S, Chen X. A New 18F-Labeled BBN-RGD Peptide Heterodimer with a Symmetric Linker for Prostate Cancer Imaging.Amino Acids. 2011 Jul;41(2):439-47.IF=3.877
17. Yang M, Gao H, Yan Y, Sun X, Chen K, Quan Q, Lang L, Kiesewetter D, Niu G, Chen X. PET imaging of early response to the tyrosine kinase inhibitor ZD4190. Eur J Nucl Med Mol Imaging. 2011 Jul;38(7):1237-47. IF=5.036
18. Wang K, Wang K, Shen B, Huang T, Sun X, Li W, Jin G, Li L, Bu L, Li R, Wang D, Chen X. MR Reporter Gene Imaging of Endostatin Expression and Therapy. Mol Imaging Biol. 2010 Oct,12(5):520-9. IF=3.844
19. Jacobson O, Zhu L, Ma Y, Weiss ID, Sun X, Niu G, Kiesewetter DO, Chen X. Rapid and Simple One-Step F-18 Labeling of Peptides.Bioconjug Chem. 2011 Mar 16;22(3):422-8.IF=5.001
20. Zhao D, Tu Y, Bu L, Wan L, Huang T, Sun X, Wang K, Shen B*. In vivo monitoring of angiogenesis inhibition viadown-regulation of miR-21 in a VEGFR2-luc murine breastcancer model using bioluminescent imaging.PloS One2013 Aug 8;8(8):e71472IF: 3.73
21. Jacobson O, Zhu L, Niu G, Weiss ID, Szajek LP, Ma Y, Sun X, Yan Y, Kiesewetter DO, Liu S, Chen X. MicroPET Imaging of Integrin α(v)β (3) Expressing Tumors Using (89)Zr-RGD Peptides.Mol Imaging Biol. 2011 Dec;13(6):1224-33.IF=3.844
22. Lang L, Li W, Jia HM, Fang DC, Zhang S, Sun X, Zhu L, Ma Y, Shen B, Kiesewetter DO, Niu G, Chen X. New Methods for Labeling RGD Peptides with Bromine-76.Theranostics. 2011;1:341-53. IF=7.804
 
BOOK CHAPTERS:

Sun X, Shen B at el. Members of Molecular Imaging, Demos Sanitation Publishing Company,2007, October.
Sun X, Shen B at el. Members of Molecular Imaging, Demos Sanitation Publishing Company,2010, October.
Sun X, Shen B at el. Members of Molecular Imaging——Principles and Practice, Demos Sanitation Publishing Company, 2013, September.

RESEARCH GRANT:
1.
Source: National Natural Science Foundation of China
Title: Molecular Imaging of NSCLC EGFR   mutationIn Vivo
Role: Principal Investigator
Period Covered: 01/01/15 to 12/31/18
2.
Source: National Natural Science Foundation of China

Title: Assessment of Early Vascular Response   UnderAbraxane Therapy Using 18F-FPPRGD2 PET and DCE-MRI

Role: Principal Investigator
Period Covered: 01/01/12 to 12/31/14
3.
Source: China Postdoctoral Science Foundation (special programs)
Title: Molecular Imaging of NSCLC EGFR   mutational status
Role: Principal Investigator
Period Covered: 01/01/13 to 12/31/14
4.

Source: The Youth Science WU LIANDE Foundation of Harbin Medical University
Title: 18F-FPPRGD2 molecular Imaging of Abraxane therapy response
Role: Principal Investigator
Period Covered: 01/01/2011 to 12/31/13
5.
Source:
China Postdoctoral Science Foundation

Title: Specific Molecular Imaging and Therapy response monitoring of NSCLC
Role: Principal Investigator
Period Covered: 01/01/12 to 12/31/13
6.

Source: The Fourth Hospital of Harbin Medical University Fund for Distinguished Young Scholars
Title: Differentiation between   recurrent gliomasandradiation-induced brain injuries using DCE-MR
Role: Principal Investigator
Period Covered: 01/01/2013 to 12/31/15
7.
Source: Heilongjiang Province Department of Education Science and Technology Research Projects
Title: Targeted Molecular Imaging   of EGFR
Role: Principal Investigator
Period Covered: 01/01/2012 to 12/31/14
8.
Source: Heilongjiang Postdoctoral Science Foundation
Title: Targeted Molecular Imaging and Therapy response monitoring of NSCLC
Role: Principal Investigator
Period Covered: 06/01/12 to 12/31/13
9.
Source: Heilongjiang Provincial Education Departmentbilingual educationFoundation
Title: Medical Imaging
Role: Principal Investigator
Period Covered: 01/01/12 to 12/31/13
10
Source: The Scientific ResearchFoundation of Graduate School of Harbin Medical University
Title: Optical imaging of RNAi therapy for breast cancer with siRNA of EGFR targeting mediated by a non-viral delivery system
Role: Principal Investigator
Period Covered: 01/01/09 to 12/31/10

INTERNATIONAL CONFERENCEPRESENTATION:
1. A Novel SPECT Probe for Targeting Mutated EGFR. Poster presentation 2014.9Seoul
2. Assessment of Early Vascular Response UnderAbraxane Therapy Using 18F-FPPRGD2 PET and DCE-MRI World molecular imaging congress. Poster presentation 2011.9 San Diego
3. Phage Display Derived Peptides for Osteosarcoma Imaging RSNA. Oral presentation 2010.11 USA Chicago Travel award
4. Comparison of the accuracy of subtraction CT angiography performed on 320-detector row volume CT with conventional CT angiography for diagnosis of intracranial aneurysms RSNA. 2010.11 USA Chicago
5. 18F-FPPRGD2 and 18F-FDG PET imaging of Abraxane therapy response World molecular imaging congress. Oral presentation 2010.9 Japan Kyoto
6. Phage Display Derived Peptides for Osteosarcoma Imaging  Japan Kyoto World molecular imaging congress. Poster presentation 2010.9 Japan Kyoto
7. Imaging guide immunotherapy of head-neck squamous cell carcinoma with cetuximab in animal models poster presentation world molecular imaging congress  poster presentation  2009 Sep. Canada Montreal

8. Susceptibility weighted imaging (SWI) shows high sensistivity towards cerebrovascular disease European Society of Radiology(ECR)poster presentation  2010.3
9. MR-CT calcification imaging European Society of Radiology(ECR)poster presentation  2010.3